This paper aims to analyze some of the main issues surrounding the national and global emergency responses to the COVID-19 pandemic through the quality lens and data driven approach of the Lean Six Sigma Define Measure Analyze Improve Control (DMIAC) methodology. The novel coronavirus (COVID-19) is a newly observed respiratory illness that began to spread at alarming rates in Wuhan, China.  Currently, there is not a vaccination or treatment. Our focus is on the Emergency Preparedness Response for the US Health Departments and global health  authorities.  During this pandemic, the Critical to Quality (CTQ) indicators are: real time communication, supplies and professional protective equipment availability and rapid recognition surveillance.  US government supply chain relief effort rely on established memorandum of agreement and understanding.  Supply Chain for humanitarian missions have many levels of complexities but is proven effective.