Six Sigma project prioritization and selection process is multi-faceted in nature. Prioritizing and selecting appropriate Six Sigma projects and allocating appropriate resources accordingly are the two critical success factors in Define-Measure-Analyze-Improve-Control (DMAIC) process. Implementing a systematic Six Sigma project selection method affecs the allocation of limited resources aligned with the strategic direction and competitive advantages of the organization. This study develops a methodology using KEMIRA-M method to prioritize and select alternative Six Sigma projects in healthcare organizations. Decision making processes in healthcare industry are affected by a great variety of stakeholders and market dynamics including caregivers and patient expectations, regulations, compliance with regulatory requirements, and the voice of the operational processes. Similarly, Six Sigma project prioritization and selection process in healthcare industry is impacted by multiple goals and objectives, criteria, factors, and stakeholders. In this study, each potential project was ranked based on their performance values of cost and benefit types of criteria. As the first implementation of KEMIRA-M weighting procedure, the criteria weighting procedure of the KEMIRA-M method was developed using two different weighting methods based on ranking. The study reveals that the Six Sigma project prioritized by KEMIRA-M assign the highest ranks to patient satisfaction, revenue enhancement, and sigma level benefit criteria, while resource utilization and process cycle time receive the lowest rank.