Limited and expensive land aqusitions require the development of buildings in city areas that are built vertically upwards. So that the building structure is designed to be able to accommodate the loads that work on the building. In addition to the strength of the structure, the building must also fulfill the stiffness requirements. This work studied the effect of the use of Fixed Base and Base Isolation supports in highrise building structures. The calculation of earthquake loads used is based on the Response Spectrum Design of the earthquake in the South Jakarta area. The numerical simulation of the combined dead load, live load and earthquake load was carried out using the finite element based design tool,   Etabs version 17. The lateral earthquake load was calculated using the static equivalent load principle. The number of floor of the building studied is 40 floors with a total height of 141 m. The results showed a decrease in shear forces and moments in buildings using Base Isolation was encountered in this study. Likewise on the top floor there is a decrease in the relative lateral drift between adjacent floors in buildings that use the base isolation