This research aims to develop the interactive multimedia product based on green chemistry in the acid-base concept and to study the feasibility of the interactive multimedia. The Four D model was applied to the 4D model: define, design, develop and disseminate. The feasibility study of the interactive multimedia-based green chemistry showed that it had 83.33 % validity with highly valid criteria. The feasibility study of the student worksheet, the syllabus, the lesson plan, the scientific literacy, and creative thinking instruments was gained 82.50 %, 89.06 %, 87.96 %, 80.00 %, and 62.50 % respectively. In conclusion, the interactive multimedia product based on green chemistry in theacid-base concep twas feasible to be applied in chemistry learning processes.