Nowadays, organizations face an industrial revolution, also known as Industry 4.0. Since it is a fairly recent phenomenon, many companies wonder how to embark on these digital transformation initiatives and do it successfully. Information Systems (IS), already present in the vast majority of companies, are shown to be one of the most important pillars within the digital transformation. This work aims to explore the Critical Success Factors that may contribute to a successful implementation of IS within a digital transformation initiative, based on a practical case carried out in an automotive industry company, where a digital transformation initiative was followed. The results point to the existence of some key factors for the success of IS implementation within this type of initiatives, such as: the existence of reliable connectivity between devices, the involvement of users in each phase of the systems’ development, the analysis of the existing processes, a good relationship with business partners that provide technological solutions and support them, and, also, the definition of strategic plans and roadmaps