Sensitivity analysis is one of the most popular technique in modelling and optimization to understand how parameters influence the optimal objective function value. In this paper, a sensitivity analysis is performed to determine the most influential parameters in multiple cyclone arrangements optimization problem, including sensitivities of input feed conditions and constraints of decision variables with respect to the minimum total cost. A combination of two types of cyclone, i.e., 1D3D and 2D2D in multiple arrangements will be involved in the study. The analysis method used in this study has demonstrated the goodness and the applicability of proposed model in obtaining the best pollution control strategies to achieve a minimum level of pollution reduction.