Safety is an important issue in the rapid industrialization especially in chemical industries. The objective of this study is to investigate relationship between safety climate factors and safety performance in chemical industries and proposes a new framework. This study uses safety management, work pressure, safety competence, safety procedures, safety communication and safety supervision as independent variables that explain the relationship towards safety performance in chemical industry at Pasir Gudang, Johor. A survey instrument was developed, and 220 responses were collected. Factor analysis and multiple linear regression was used to analyze the data collected using SPSS software. As a result, safety climate factors (safety management and work pressure, safety competence, safety communication and safety procedures) were able to explain 47.2% of variation safety performance. Nonetheless, it was found that reflections of safety climate factors on safety performance could not be similar with each industry, since findings would fluctuate due to geographical context and individual context. Despite the limitations, this study contributes to the literature by revealing table factor structures, where appropriate level of reliability and validity measures of safety climate factors and safety performance scales were developed.