It is suspected that male and female students at the Faculty of Science and Technology, Universitas Terbuka, have different levels of academic achievement. This paper aims to analyze the differences in academic achievement between male and female students at the Faculty of Science and Technology, Universitas Terbuka. In this paper is a comparative study with a quantitative approach. The population in this study were students of the Faculty of Science and Technology, Universitas Terbuka. The sampling technique uses the Proportional Stratified Random Sampling method. Data collection is done by means of documentation. The data obtained were analyzed using descriptive and inferential statistics with the t-test technique. The results of the study descriptively showed that the average GPA of male students was 1.87 and the average GPA of female students was 1.98. The results of hypothesis testing using t-test obtained Sig (2-tailed)> absent or (0.153> 0.05). This shows that between male students and female students at the Faculty of Science and technology, Universitas Terbuka, there was no significant difference in academic achievement. The implication of the results of this study is that students should exchange information more frequently without looking at gender.