Reentrant flow lines is a special type of production flow lines where a job may visit a machine or group of machines more than once. This reentrancy characteristic results in higher variability of cycle time and throughput rates when compared to traditional production flow lines. Complex reentrant flow of jobs are closely related to semiconductor wafer fabrication due to layering of wafers, which is one of the most complex processes in semiconductors manufacturing. This paper presents a simulation study that seeks achieving a target throughput rate while improving cycle time using the segmented CONWIP lot release policy, which basically entails division of the production line into segments of similar total processing times and controlling the WIP level in each segment using CONWIP. A highly re-entrant and representative wafer fabrication facility found in literature is used for this study. Different scenarios that varies the number of segments, WIP level of each segment, and their combinations are tested using simulation. Results analysis shows that line segmentation using different CONWIP levels affects the line performance. In fact, in some instances, compared to a single segment CONWIP and push system, using segmented CONWIP can achieve the same throughput rate in a shorter cycle time