Indonesia is one of the largest Crude Palm Oil (CPO) producing countries in the World besides Malaysia, although the reality is still in the middle-income country grouping or developing based on the level of people's welfare, where one of the problems faced by developing countries including Indonesia is the slow growth rate industry. The growth of the CPO industry can be said to be very important in measuring the success of economic development. This is because the growth of CPO industry is one indicator to show the level of prosperity as a result of the development of large medium industry (IBS) and small mined industry (IMK). The increasing CPO industry growth in Indonesia is followed by a small mined industry index (IMK), national economic growth and increased Bank Indonesia (SBI) interest rate, could result in the Large Medium Industry Growth Index (IBS), Inflation Rate (IF) And the decreasing unemployment rate (PGN). The Growth Rate of CPO Industry in Indonesia is relatively high because it achieves two (2) digits during the period of 1997 to 2015 with an average of 12.566 percent per year. The high growth of Indonesia's CPO industry has resulted in changes in industrial structure and macroeconomic conditions in Indonesia. The purpose of this research is to analyze the influence of factors influencing the growth rate of CPO industry in Indonesia. Based on the calculation of multiple regression analysis, it is found that the variables of industry index minus (IMK), Interest Rate of Bank Indonesia, national economic growth rate (GDP) have positive and significant effect [1,170; 0,811; 2,833]. While the variable of Industrial Development Index of Large-Medium, Inflation rate, Unemployment Rate (PGN) have negative and significant effect [0,436; 2,422; 5,150] to CPO industry growth rate in Indonesia.