The purpose of this research was to determine whether the Third Parties Fund (TPF), Non Performing Loan (NPL), Capital Adequacy Ratio (CAR), Loan to Deposit Ratio (LDR), Return On Assets (ROA), Net Interest Margin (NIM), and Operating Expenses Operating Income effect on lending in regional development banks in Indonesia. Object in this study is a regional development banks in Indonesia 2010-2014 (26 banks). Methods of data collection is the historical data with data analysis techniques that multiple linear regression analysis. While hypothesis test using t - test to test the effect of partial variable and F-test to test effect of simultan variable. The results showed that in simultan, all independent variable (TPF, NPL, CAR, LDR, ROA, NIM and BOPO) influence on dependent variable (lending). The results showed that in partial, Third Parties Fund (TPF), Loan to Deposit Ratio (LDR), Capital Adequacy Ratio (CAR) and the Return on Assets (ROA) positive and significant impact on lending. Variable Operating Expenses Operating Income a significant negative effect on the loan portofolio, while the variable Non Performing Loan (NPL) has no effect on lending. The most dominant independent variable affecting on lending of regional development banks in Indonesia is Third Parties Fund  (TPF)