This paper presents an inclusive review on the application of Lean Six Sigma for strategic transformation of business process in a power generation organization. In today’s very competitive business environment around the world, organizations need to be lean and mean as their source of competitive advantage. This is no different for the company under study. The organization enjoyed steady growth in profit since its involvement in power generation business. However, it is becoming more apparent that the organization needs to review its internal business process in order to operate at its optimum level. One of the options is to implement Lean Six Sigma. In year 2016, the management has decided to deploy Lean Six Sigma as a structured methodology to enhance the organizational performance. The organization has chosen to embark on Lean Six Sigma journey in conducting its business process transformation and improvement as well as cost optimization as the means to improve its profitability. This study attempts to evaluate the effectiveness of the implementation. The research is to explore in depth on the characteristics of Lean Six Sigma methodology and the factors which may influence its implementation. The challenges faced during the journey were examined to identify the limitations of the Lean Six Sigma methodology and any improvements that can be introduced to enhance its effectiveness.