Today healthcare service has offered the modern treatment approach with medical technology. This kind of technology has become such a predominant part of healthcare service because no practical diagnosis or treatment strategy is possible without using them. The advancement of technology is also driving medical companies with great opportunities to take a new innovative product into market. In addition, company could not focus solely on large amount of volume and low production cost to keep up growth, however, they have to control its direction towards quality trusted for usage. Meanwhile, climate change and pollution is increasingly unprecedented before and putting burdensome on this sector, which is lacking behind other sectors, to become sustainable manufacturing organization. That is true that medical device industry considers safety, usability and efficacy of product, but product design and development is a major role behind these factors. Sustainable design, sometimes called green design, has become a globally significance topic but not many works of academic papers are directly targeted to the medical device product. Therefore, the purpose of this study is initially conducted to identify influencing factors and then determine key improvement recommendation for sustainable development of medical device. Analytic Hierarchy Process (AHP) is used to prioritize the influencing factors and Quality Function Deployment (QFD) is used to find the key improvement attributes recommendation. The result of this study shows linear relationship between product user and developer towards quality and sustainability of product. It is found that the most of the top concerns of device users are not only safe for present use but also recyclability, which product can be made for environmental conservation, at the end of its life.