In today’s society that disasters seem to be striking all corners in Bangladesh and the globe, the importance of emergency management is undeniable. Much human loss and unnecessary destruction of infrastructure can be avoided with more foresight and specific planning. Most of the people die due to lack of medicines and proper treatment so it is necessary to supply first aid medicines right after any severe disaster. The goal of this paper is to develop a comprehensive model that involves transporting medicines from different supply sources to different distribution centers in response to Cyclones in the southwest coastal areas of Bangladesh to maximize the survival rate of the affected population, which is modeled using linear programming in order to find the optimal quantity of cartons containing medicines which will be supplied to affected people and also the optimal transportation cost and time. Excel Solver and simulation software Analytica® Optimizer has been used to model and solve this problem.