World population is rapidly increasing over time along with the people’s demands in terms of health. Pharmaceutical companies in the Philippines continue to produce medicines to accommodate the demands nowadays. They assure that every product is in good quality and meeting the customer’s expectations and standards. Thus, Philippine pharmaceutical companies focus on the workers’ sustained attention resulting to be as efficient and effective in doing their job. Through assessing the workers’ attention level, approximately sixty percent (60%) fall under 9,200ms which is considered to be low attention level that results to a high number of non-conformity products. To lessen this, researchers identified the significant factors affecting the workers’ sustained attention. Sustained attention to response task (SART) was used in measuring the workers’ attention level. The collected data were found normally distributed through the normality test, having a p-value of 0.095. Significant factors were identified with the use of multiple regression; however, BMI (0.237), working years (0.854) and noise (-0.724) were found to be positively weak, positively strong and negatively strong correlated with the sustained attention level. The recommendation presented in this research is ergonomic based intends to improve production workers’ sustained attention in pharmaceutical companies in relation to the abovementioned significant factors.