Numerical Simulation of Interferon Alpha (INF-α) in Mathematical Model of Immunotherapy

Subiyanto, Subiyanto; Sukono, F; Supian, Sudradjat; Hidayat, Yuyun; Sambas, Aceng; Mamat, Mustafa; Talib Bon, Abdul

doi:10.46254/AN09.20190390

Modeling and Simulation

Numerical Simulation of Interferon Alpha (INF-α) in Mathematical Model of Immunotherapy

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Subiyanto Subiyanto Universitas Padjadjaran

F Sukono Universitas Padjadjaran

Sudradjat Supian

Yuyun Hidayat Department of Statistics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Indonesia

Aceng Sambas Universitas Muhammadiyah Tasikmalaya

Mustafa Mamat Universiti Sultan Zainal Abidin

Abdul Talib Bon Department of Production and Operations, University Tun Hussein Onn Malaysia

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In this paper, the effect of boosting interferon alpha (INF-a) in immunotherapy by using mathematical modeling was analyzed. In this model, tumor growth is described as a tumor cells population with immunotherapy. This model also describes the effect of interferon alpha (INF-a) on dynamics of tumor cells. Numerical modeling of immunotherapy with or not boosted interferon alpha (INF-a) is presented in this paper. We obtained that boosting interferon alpha (INF-a) in immunotherapy have a very significant role in killing of tumor cells. Interferon alpha (INF-a) that administered in 4 pulses from day 1 to day 34 to strength 4.8 can still kill the tumor, but when it was reduced to strength 4.7 cannot kill the tumor.

Published in 9th Annual International Conference on Industrial Engineering and Operations Management, Bangkok, Thailand

Publisher IEOM Society International

Date of Conferences March 5–7, 2019

ISBN 978-1-5323-5948-4

ISSN/E-ISSN 2169-8767

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Numerical Simulation of Interferon Alpha (INF-α) in Mathematical Model of Immunotherapy