As the Internet continues to reach more homes and businesses across the world, this has created more opportunities for retailers to expand across global boundaries. One of the fastest growing markets that retailers are looking to expand is countries that belong to the Gulf Cooperation Council (GCC) for Arab States. This research investigates consumers’ intention to adopt e-commerce by gender between young professionals. The aim of this research is to understand gender differences between two groups, namely, Westernized Saudi Arabians that reside in the United States and Non-westernized Saudi Arabians that reside in Saudi Arabia. Since culture and environment are of high regards in Saudi Arabia, a change in their environment could affect Saudi Arabians’ intent to use e-commerce. Gender and other factors could also affect these two group’s intention to use e-commerce freely. Thus, this research will present the theoretical model termed Human Factors e-Commerce Acceptance Model (HFe-CAM), and an e-commerce acceptance questionnaire.