Supply chain performance evaluation is a critical and difficult task in supply chain management. This paper presents a performance evaluation framework to evaluate and compare the performance of different supply chains. The framework is based on Data Envelopment Analysis (DEA) as a data oriented tool for evaluating the performance of several supply chains that convert multiple inputs to multiple outputs. The objectives of this study are: (a) to construct a set of aggregated indicators that best characterize the performance of supply chains (b) to estimate the relative technical, pure technical and scale efficiencies of supply chains and interpret the results, and finally (c) to estimate the magnitudes of input adjustments that would have been required to make each supply chain efficient. The proposed approach is then applied to evaluate real-life public pharmaceutical products supply chains in Morocco.