Currently considering the challenges and vary in the need for Fourth Industrial Revolution among developing countries, there is a continuous need for higher education institutions to consider the optimal value derived from harnessing Fourth Industrial Revolution for improving its poor educational infrastructure in their universities. Consequently, there will be strong demand for professionals who can blend digital and STEM skills with traditional-mechanical engineers and business operations data analytical tools to quickly adapt business strategies and it’s for this reason that they need to ensure the “future readiness” of curricula, this requires universities to develop not just skills needed today but also those that will leverage the technological advances of tomorrow. This paper employs wide-range systematic reviews to drive the requisite of universities in developing countries to harness the fourth industrial revolution in order to improve poor infrastructure in its universities. The aim of this research is to analyze the Fourth Industrial Revolution approaches required to be implemented within universities to improve poor infrastructure, the motives behind this and the actual function of the Fourth Industrial Revolution within the University system. Also, this study aimed to recommend the most effective Fourth Industrial Revolution approaches which may lead to the highest satisfaction of students' needs for the various universities' infrastructure within the developing countries.