For any organization aiming to achieve sustainable quality culture of operational excellence, it is important to ensure that a proper foundation for a company-wide quality (CWQ) culture exits. This foundation is a comprehensive company-wide management system (CWMS) which can serve as an infrastructure for improving and controlling the different operation systems of any organization. The CWMS mainly draws on five MSs, strategic management, initiative management, daily management, process management and performance management. It ensures the proper alignment of all people and processes, the optimization of resources and sustainability of high performance. For any organization to succeed in meeting high-quality standards, the existence of quality culture is essential and this requires time and commitment. One key enabler of that is the CWMS and Lean Six Sigma (LSS) Methodology. This paper will explain how their proper implementation will sustain the quality culture and enable it to spread and take over. This paper follows a theoretical review of literature combined with the authors’ own experience to discuss CWMS, sustainable quality culture and the LSS culture-related aspects.