Ponorogo Regency has many small and medium enterprises (SMEs) that produce furniture. Unfortunately, these SMEs are still managed at a home industry scale and lack information to develop. In Industry 4.0, there are many opportunities for districts to go to smart cities. A new paradigm is needed in the management of the SME industry. This is necessary to develop and support SMEs through the development of industrial centers for small and medium enterprises within the framework of smart cities. Therefore, this study was conducted to determine the location of the SME center to support government policies in managing and developing SMEs. To identify the optimal location of the information center, we propose a center of gravity and a huff model to determine the location of the industrial  center for SME. Finally, this paper describes the results of the implementation of the SME center in the furniture industry.