In this work, the author developed a knowledge-based system for ergonomic application in manufacturing (KBSEAM) which is helpful to solve the ergonomic related issues in small and medium scale manufacturing organizations. Generally, budding entrepreneurs have very limited knowledge about the application of the ergonomic tool in the manufacturing sector. This software is introduced to create this awareness and to make them initiate the use of these ergonomics tools their industries. This software guides the users in understanding the fundamentals of ergonomics and also helps a new entrepreneur in providing the guidelines for considering ergonomic issues in a unit for small and medium-scale organizations. The software provides the various ergonomic assessment tools which can be used to assess the ergonomic issue prevailing in the workers during work such as MSDs, Strain on worker mental health and safety issues. Furthermore, a case study of an Indian Saw-mill is taken to assess the working condition of the worker during work and relative actions were suggested to rectify the work methods.