This study developed a mathematical model for a Closed-Loop Supply Chain (CLSC). It considered the Single Set-up Multiple Delivery Policy, carbon emission of industrial and transportation of the CLSC, and self-healing packages. The model was able to show that utilizing the self-healing packages can lessen the carbon emission and the total cost throughout the process. Moreover, the results show that most of the parameters had a significant change in the total cost after undergoing sensitivity analysis. This numeric behavior was evident due to the relation of the assumed equal demand throughout the whole process of the CLSC. However, there are also parameters that showed an inverse relationship and infinitesimal effect on the total cost. This occurred due to the utilization of the CSLC and self-healing packages. Lastly, the application of this study can benefit the optimization of the closed-loop supply chain and organizations that utilizes the CLSC and self-healing packages. Companies can utilize the model to have a competitive edge and promote a green supply chain.