This study aims to evaluate and examine the impact of leadership, organizational culture, and administrative performance management systems at Hasanuddin University Hospital Makassar. This research was conducted at Hasanuddin University Hospital Makassar from June to July 2020. The study method used is survey research using cross-section data, where information is obtained from respondents using a questionnaire whose population data is focused on the fact that all members of the population are sampled, namely 87 employees. The path analysis is used for statistical research. The findings indicate that leadership has a significant favourable influence on Hasanuddin University Hospital's organizational success in Makassar. The administration has a positive and considerable impact on the control system at Hasanuddin University Hospital in Makassar. Corporate culture has a positive but negligible effect on organizational success, and organizational culture has a positive and significant influence on the control system at Hasanuddin University Hospital in Makassar. The control system has a positive and substantial effect on the Hasanuddin University Hospital's organizational efficiency in Makassar. Leadership has a positive but no considerable impact on organizational success through the control system at Hasanuddin University Hospital in Makassar. Corporate culture has a positive but negligible influence on organizational success through the control system at Hasanuddin University Hospital in Makassar.