Quality infrastructure has an important role in supporting national economic development. The quality infrastructure consists of four core pillars: standards, accreditation, metrology, and conformity assessment services. ISO/IEC 17025: 2017 regulates general requirements for the competence of calibration laboratories. In several countries, the number of accredited calibration laboratories is only one-fifth of the testing laboratories. Currently, there is not much research on calibration laboratories. Calibration activities are an important part of the quality infrastructure system because incorrect calibration results can lead to the withdrawal of distributed products, and can lead to customer doubts about the quality of the products. The results of case studies in Indonesia require additional accredited calibration laboratories for more than 49% of the current number. This indicates the very high need for calibration laboratories has not been supported by the growth in the number of laboratories. SWOT Analysis can be used as a method to obtain internal and external factors in the accreditation of calibration laboratories in strengthening Indonesia’s quality infrastructure. The results of the research show that factor “guarantee the validity of calibration result”, “lack of National Metrology Institute capabilities” and “pre-existing structure and facilitate” significantly related to calibration laboratory accreditation.