Covid-19 pandemic has caused an increasing burden on the health system and an economic crisis. The Indonesian government has made a policy through the Decree of the Minister of Health of the Republic of Indonesia Number HK.01.07/MENKES/446/2021 regarding the use of rapid diagnostic test antigen (RDT-Ag) in the examination of Covid-19. This regulation stipulates that the use of RDT-Ag is one of the Covid-19 screening methods for contacts tracking, diagnostic enforcement and examinations under certain conditions. The supplier selection of this multi-criteria RDT-Ag test kit was carried out at the "x" laboratory. Laboratory “x” only uses the tender method, it only reviews the criteria, quality, and legality in the evaluation process for selecting RDT-Ag test kit suppliers. therefore, improvements are needed in evaluating supplier selection with multiple criteria (adding criteria/sub-criteria), the more criteria and sub-criteria used in the supplier selection process will provide a more objective supplier ranking. The main challenge in supplier selection is to formulate appropriate criteria. This research integrates the approach using the Analytical hierarchy process (AHP) and Technique for other references by similarity to ideal solution (TOPSIS). The AHP method is used to weight each criterion and sub-criteria, while the TOPSIS method is used to determine the suppliers rangking. This study uses 7 criteria and 16 sub-criteria; the criteria used are price, quality, delivery, supplier profile, flexibility, service and warranty. The weight of the three highest criteria are the supplier profile (0.434), quality (0.181) and price (0.142), with three highest supplier rangking are supplier 2 (0.664), supplier 8 (0.648) and supplier 1 (0.620).