PT ABC is a company engaged in manufacturing repackaging. PT ABC repackaged silicone sealant and continues to grow so that the company's current location does not have sufficient area and requires PT ABC to expand its production and storage area. Due to insufficient space, the current factory layout has an unorganized flow of manufacturing operations, causing the production process to become ineffective and inefficient. Due to a lack of space, PT ABC's raw materials and completed goods are also stacked haphazardly. As a result, the new factory's layout design is carried out utilizing Systematic Layout Planning (SLP) and CORELAP methodologies and the Artificial Neural Network (ANN) method for forecasting. The results were presented in two SLP alternative designs and one CORELAP method design. The optimal option is the shortest distance and lowest material handling expenses. The SLP 1 design, with a distance of 223.14 meters and a material handling cost of IDR 5,810,741.66 per week, is the most effective solution. ProModel simulation is used to put the layout into action.