ISO 9001 is a series of quality management system standards which provide guidance and tools for companies and organization to ensure that their products/services consistently meet customer requirements. Adamson University applied for and successfully achieved the prestigious ISO 9001:2008 Management Systems certification by TÜV Rheinland. The ISO 9001:2008 certification means that the quality of the university’s processes and standards are at par with international management systems and that the University has instituted quality assurance methods in both the academic and support services with procedures for its maintenance. The goal of this research is to identify the success of the ISO 9001 program and its contribution to the success of operational efficiency in Adamson University. The data were gathered from the survey questionnaire answered by selected employees of Adamson University. The findings of this study were based on the answers of one hundred twenty-five (125) respondents. Finally, the analysis of data was accomplished by descriptive statistics to find the results and conclusion. Resource Management is the only significant factor among the components of Quality Management System that has significant effect on the scores on the Contributions of ISO. Also, employees’ assessments for all the components of Quality Management System are positively correlated with both Contribution of ISO and the Ratings of Success in improving operational efficiency. These significant positive correlations have shown that the ISO program of Adamson University is associated to the success in improving operational efficiency of the employees positively.   Lastly, the main contribution of ISO 9001 Quality Management System focused on customer focus, improvement, process approach and engagement of people within the organization. Employees elaborated that ISO contributed to the operational efficiency in Adamson University by making their work more efficient, improving work flow, improving customer focus and organized process and documentations. Moreover, the result in ANOVA implied that there is no significant difference on the contribution of ISO 9001 on different offices in Adamson University. The researchers therefore recommended having twice every year internal audits that will help the management review the irregularities and plan what action should be performed in order to control and solve the problems and issues immediately. Since the success and contributions of ISO program in Adamson University were being felt and observed by the employees, the researchers recommended for continuously sustaining the ISO 9001 Certification for process improvement.