With the rise of diverse transportation options worldwide, companies now consider various factors in mobility and delivery. Motorcycle taxis have become widely available and are rapidly transforming the transportation scene in the Philippines. Due to increasing commuter demand, tens of thousands of additional ride-hailing motorcyclists are needed, leading to continuous growth in this sector. Despite its expansion, a significant research gap exists. Most studies focus on risk factors without incorporating "pain level" as a measure for identifying musculoskeletal disorders (MSDs) among ride-hailing motorcyclists. This study addresses that gap by examining the correlation between risk factors and the pain levels of MSDs among ride-hailing motorcyclists in the Philippines. The primary objective is to determine the significant risk factors influencing MSD-related pain. The research focuses on male ride-hailing motorcyclists aged 21–55 in Metro Manila, utilizing surveys, interviews, and observations for data collection. Multiple linear regression analysis with "pain level" as the dependent variable is employed. Findings indicate that weight, alcohol consumption, motorcycle vibration, and riding duration significantly impact MSD-related pain levels. These factors contribute to work-related musculoskeletal disorders (WMSDs) among ride-hailing motorcyclists. To mitigate risks, the study recommends careful monitoring of rider weight, reducing alcohol intake, regular motorcycle maintenance, and limiting travel to 7–9 hours per day to minimize fatigue. Addressing these factors can improve rider well-being and work efficiency, reducing the prevalence of WMSDs among motorcycle taxi drivers in the Philippines.