This article aimed at determining the role of Academic Information System in improving student satisfaction in higher education institutions. This research used quantitative approach and the research objects were students of STIE Enam Enam of Kendari. The purposive sampling method and Slovin formula were used in the sample determination and 91 students were selected as samples in this study. By using multiple linear regression analysis, the study found that Academic Information System and Service Units performance simultaneously have a significant effect on student satisfaction. In addition, partially, Academic Information System affects student satisfaction while the performance of Service Units has no significant effect on student satisfaction. The results of this study confirm and at once different from the previous studies that have been conducted.