This study explored the relationship of multiple factors on the criticality of road traffic accidents in CALABARZON Philippines. Five thousand data points from DOH hospital records were used to generate a statistical analysis that can interpret the relevance of each factor on road traffic accident criticality. The significance of each factor was verified through one-way ANOVA. The criticality of road traffic accidents is measured using mean and standard deviation. Results showed that large vehicle size is most likely to cause critical accidents. Driver's age is also a predictor of road accident criticality. It suggests that older drivers are more likely to be involved in critical road accidents than younger drivers. The criticality of road traffic accidents is also dependent on the congestion of the road. The highly congested road tends to limit the driving speed, which reduces the fatality of accidents. From these results, it is highly suggested to impose stricter traffic laws on vehicles that have a larger size. Also, this study recommends the renewal of a driver’s license since age has a strong positive correlation with the criticality of traffic accidents. Overall, this study was able to predict the impact of each factor with the criticality of traffic accidents.