This study aims to find room head supervision and the nursing staff's knowledge on patient safety through the quality of nursing services at the West Sulawesi Provincial Hospital. In this study, the research design used was an analytical survey with a quantitative approach. The sample in this study were all nurses in the West Sulawesi Provincial Hospital's nursing room, which were taken using a non-probability sampling technique using a proportional random sampling technique. This study's population was 167 respondents, who were analyzed using path analysis with multiple linear regression tests. The results showed that: 1) the head of the room's supervision on the quality of nursing services in the West Sulawesi Provincial Hospital had a positive and significant effect. 2) The nurses' knowledge of the quality of nursing services in West Sulawesi Provincial Hospital has a positive and significant impact. 3) Supervision of the head of the room on patient safety has a positive and significant effect. 4) The nurse's knowledge of patient safety has a positive and significant impact. 5) The quality of nursing services on patient safety has a positive and significant impact. 6) Supervision of the head of the room on patient safety has a positive but insignificant relationship through the quality of nursing services at the West Sulawesi Provincial Hospital. And 7) the knowledge of the nurse administrators on patient safety is positively related but not significant through the quality of nursing services in the West Sulawesi Provincial Hospital.