This study intends to analyze the effect of work experience and motivation on nurses' performance through caring behavior in the inpatient room of the Labuang Baji Makassar Regional General Hospital. The research design used in this study was a survey with a quantitative approach. The study population was the nurses in the inpatient room of the Regional General Hospital Labuang Baji Makassar. The method of determining the sample used in this study using an accidental sampling technique with a sample size of 122 respondents. This test uses a multiple linear regression test and path analysis. The results showed that the researcher gave 122 questionnaires according to the sample in the inpatient room and sent back 104 questionnaires with the results are: (1) work experience having a positive effect on caring behavior, (2) motivation has a positive impact on behavior, (3) affectionate behavior has a positive impact on performance, (4) work experience hurts nurses performance, (5) motivation harms the performance of nurses, (6) work experience indirectly through caring behavior harms the performance of nurses and (7) cause indirectly through watching the action in the inpatient room of the Regional General Hospital Labuang Baji Makassar hurts the performance of nurses.