The role of stressors is recognized as critical for human resource development and management issues where it can have an impact on occupational stress and performance blue-collar employees in the pharma manufacturer division. The employees themselves developing various kinds of stress factors that may interfere with the implementation of the work. According to these conditions, the role of an organizational change related to work pattern hours, shift handover and workdays is an unavoidable policy of management change. This study was conducted to determine the effect of several stress factors, especially for the policy of management change on occupational stress and performance blue-collar employees in the production division. The outcomes of Smart PLS 3.2.9 path model revealed findings for blue-collar employees (360 respondents) role in the organization significantly correlated with employee’s stress (T = 3.305; p-value = 0.001) and also significantly correlated with performance (T = 3.268; p- value = 0.001). The indicator that has the highest factor loading value of the role of the organization is the work pattern hours. A negative relationship was established between stress to performance of blue-collar employees.