Track: Industrial Management

Abstract

The main causes of hyperlipidemia include the consumption of a high-fat diet, which results in atherosclerosis and heart disease. Prevention of hyperlipidemia can be done by consuming foods rich in antioxidants, such as anthocyanins contained in black rice bran. This study aims to evaluate the anti-hyperlipidemic effect on soy fortified with black rice bran extract on humans, which in research conducted on Wistar (Rattus norvegicus) rat research animals. This study aims to evaluate the effect of anti hyperlipidemia on soygurt enriched with black rice bran extract on Wistar (Rattus norvegicus) rats. This research was conducted in vivo. Research materials included soygurt and black rice bran extract. The research stages included preparation of animal lab, 28 male Wistar rats, 3 weeks old; feed AIN-93G (G) and AIN- 93M (M); adaptation a week; depletion period for 5 weeks, until hyperlipidemia with total cholesterol levels ± 200 mg/ml and total triglycerides ≥ 150 mg/dl. Separated into 4 diet treatment groups, namely without a standard diet, M diet + demineralized water (P = placebo); M diet + soygurt dried (K = control), M diet + 50 mg black rice bran extract enriched in soygurt (S-50), and M diet + 100 mg black rice bran extract enriched in soygurt (S-100) for 5 weeks. Taken blood from retroorbital flexus, euthanization, and surgery. Analyses were changed in total cholesterol levels, total triglyceride levels. Statistical analysis was performed by analysis of one-way variants (One Way Anova) with Minitab 17 at a significance level of 5%. If there are significant differences, then proceed with the Tukey's test (p≤0.05). The results showed that the S-100 group was able to reduce total cholesterol and triglyceride levels after the end of treatment at 95.13 mg/dl and 69.55 mg/dl. Changes in total cholesterol levels during the study, namely at the early until the induction increased by 57.19% and the induction to the end decreased by -48.19% had a positive effect on the treatment of S-50 and S-100 reducing total cholesterol levels. Whereas for the total triglyceride levels during the study, at the early until the induction increased by 46.51% and the induction to the end decreased by -48.42%, a positive effect of the treatment of S-50 and S-100 decreased total triglyceride levels.