Businesses define and manage Key Performance Indicators (KPI’s). The most effective KPI’s for business optimization is the subject of various studies. Various best practice bodies dedicate significant effort in defining smart KPI’s. The Fourth Industrial Revolution (4IR) is able to digitalize the business so as to automate and collect data, facilitating digital constructs of defined KPI’s. 4IR introduces Big Data (BD), Big Data Analytics (BDA) and Advanced Data Analytics (ADA) for analyzing data collected from digital business integration. ADA engine generates relationships between data never conceived historically. The ability of business to apply the theoretical correlations for business optimization is a contemporary challenge. Artificial Intelligence (AI) spawns mechanisms that enable machines to be intelligent enough to react like humans. However, there is a misalignment between KPI’s defined by organizations and those discovered by analytics. This research proposes an approach to synergizing and developing smart KPI’s by bringing together 4IR and traditional approaches.