Indonesia is one of the leading steel producers in Southeast Asia with the second highest production value after Vietnam. For the sake of good business processes and legitimacy, several steel producers in Indonesia have followed international standards in occupational health and safety management such as OHSAS 18001 and ISO 45001. In order to continuously improve the performance of the Occupational Health and Safety Management System, the company uses the Deming Cycle in its implementation. The steps taken to improve the performance are through commitment and leadership, followed by planning with context analysis, operational planning, risk assessment and control. In the implementation process, identification is also needed to measure and develop individual and team performance in order to align performance with the strategic goals of the organization or company. In other words, ISO 45001:2018 and performance management can affect the level of work accidents and company performance, so an analysis is needed to determine the effect of ISO 45001:2018 and performance management on work accidents and company performance. The results of this study are ISO 45001:2018 has a positive and significant effect on work accidents while performance management has no effect on work accidents. The next result is ISO 45001:2018 and performance management has a positive and significant influence on company performance. Meanwhile, work accidents have no effect on company performance.