This study aimed to determine a framework for developing technopreneurship and innovation systems in agricultural drone technology development in Indonesia. The methodology used in this research is a comparative study of three technology development drones in Indonesia. The research approach uses four frameworks that are combined. This framework consists of market pull vs. push technology, Process Innovation, closed innovation vs. open innovation, and the Technology Transfer Office. The data used in analyzing this comparative study is qualitative data that is secondary data obtained on the internet and previous research. The results obtained are that management and innovation systems are essential to grow and develop successful technology-based entrepreneurs, which is learned from how agricultural drone technology development in Indonesia is analyzed. At the core of their success in launching products is the management and innovation system that they do well and measure. Then the evaluation framework has been carried out, which is divided into two, namely the strategy stage and the development stage. The strategy phase consists of a Technology Push and Market Pull and Closed Innovation vs. Open Innovation framework. The development phase consists of the Innovation Process and Technology Transfer Office. This framework model is following the framework for the development of agricultural drone technology.