Track: Material Engineering

Abstract

Osteoporosis often called “silent diseases” of aging because bone loss occurs without symptoms, untuil microarchitectural deterioration and bone fractures occurs. The common therapy to prevent the estrogen degrading condition is Hormon Replacement Therapy (HRT). However, HRT possessed various risks. Recent studies suggest the phytoestrogens may exert a protective effect against osteoporosis. This study examined whether treatment with phytoestrogen extract from Pandanus odoratissimus seed (PS) exerted a preventive effect on estrogen deficiency induced osteoporosis. Three months old female Sprague Dawley rats were randomly assigned into either a sham operated group or one of five variectomy (OVX) groups, Negative control, positive control (with Allendronate) and OVX with PS extract. Rats began receiving treatment 20 days after the OVX and receiving treatment for 28 days after OVX. The results showed that PS (900mg/kb bw) treatment prevented decrease in trabecular density while also preventing an increase in trabecular separation and PS 900 mg/kg bw had the smallest proportion of osteoclast to osteoblast, compare to other treatment. The result of this study demonstrated that the potential effects of Pandanus odoratissimus seed extract (PS 900mg/kg bw) as herbal drug. Therefore it is suggested that Pandanus odoratissimus seed extract might be a potential alternative therapy for treating postmenopausal osteoporosis.