MSMEs (Micro, Small, and Medium Enterprises) play a significant role in Indonesia's economy. E-commerce has many advantages for MSMEs which includes competitive advantage, greater market share and better customer service, among others. Indonesian users are already proficient with e-commerce but unfortunately only 19% of Indonesian MSMEs have adopted e-commerce. This research investigates the variables that influence e-commerce technology adoption in Indonesian MSMEs using Technology Acceptance Model, Technology Organization Environment (TOE) framework and Diffusion of Innovation (DOI) Theory. A survey questionnaire was conducted to collect data from 260 MSME owners in the food and beverage industry who have or have not adopted e-commerce technology for their business. The result was calculated using logistic regression and Relative Importance Index (RII) to get which variables are relevant in e-commerce adoption in Indonesia MSMEs. From the research, it is revealed that relative advantage, perceived usefulness, security, employee’s IT knowledge and government’s support have a crucial influence in e-commerce adoption for MSME owners. An e-commerce adoption strategy was recommended based on the study’s results. It is focused on the most significant factors of e-commerce adoption for MSMEs to increase the chances of adoption.It is focused on the most significant factors of e-commerce adoption for MSMEs to increase the chances of adoption.