The research purpose is to assess the level of comprehension of the worker on equipment warning signs in the Philippines. To identify the factor(s) affecting the result of the comprehension score and propose an improved alternative design regarding ergonomic principles of warning sign design. A method of Analytical Hierarchy Process (AHP) employed in the selection of the most appropriate design. The result shows that more than half of the assessed warning signs fall below the standards set by the American National Standard Institute (ANSI), which leads to the proposal of alternative warning sign design. The study conducts a controlled survey to collect data from 90 respondents in the manufacturing industry. The data was analyzed by Structural Equation Modelling (SEM) using AMOS in SPSS Statistical software. The result shows a strong influence of Education and Work Experience on warning sign comprehension. The ergonomic principles show a significant impact on the improvement of comprehension level, which was confirmed using a 2-sample-t hypothesis test.