Chronic kidney disease (CKD) is among the most prevalent non-communicable diseases worldwide. Non-communicable disease-related premature mortality is prevalent in low- and middle-income nations such as Indonesia. According to government data, 718,783 CKD cases of chronic kidney disease were listed in 2018. In such instances, hospitals assume a critical function. Dialysis therapy may be considered as a treatment option. Patients undergoing hemodialysis must exhibit the capacity to adapt to various treatment protocols to mitigate undesirable fluctuations, including those caused by hypertension-induced abrupt declines in blood pressure, excessive salt consumption, and fluid overload. Therefore, hospitals and patients are responsible for monitoring and ensuring the patient's condition throughout the treatment. Consequently, design thinking and quality function deployment methods have been applied for the development of high-fidelity wireframes for intelligent monitoring. Between 2018 and 2022, the study was conducted at a hospital in Indonesia, where 3,428 patients underwent 25,313 procedures. The efficacy of the design was evaluated using a usability test, and it received a good score.