Corona Virus Disease-19 or commonly referred to as Covid-19 is a virus that first originated in the city of Wuhan, China. The rate of spread of Covid-19 is very short and also very deadly. In March 2020, the World Health Organization (WHO) declared Covid-19 a global pandemic. Since the importation of the first case in the South African Region. The coronavirus disease 2019 (COVID- 19) pandemic has spread to 46 countries of the 47 countries in the African region and caused unprecedented societal and economic disruptions. Populations are being severely impacted with measures taken to curb the pandemic. Therefore, causing hardships and socio -economic consequences. As of 3 May 2020, cumulatively, over 3.3 million confirmed cases and nearly 240,000 deaths have been reported globally from over 210 countries, areas or territories. As of 25 February 2021, cumulatively, over 111.7 million laboratory confirmed cases and over 2.4 million deaths had been reported globally from over 190 countries, areas or territories. In October to date, around 50 million COVID-19 vaccine doses have arrived in South Africa, which is almost double what was shipped in September. Forty-two percent of countries in the African Region have not yet completed district level plans for their campaigns, while nearly 40% have not yet undertaken intra- action reviews which are key to refining and improving their vaccination campaigns.