Although there has been a growing interest in the literature on supply chain ecosystems, there is still a lack of comprehensive understanding regarding ecosystems. There are gaps in knowledge, particularly in relation to the transformation of supply chains into ecosystems or their integration into existing ecosystems. While many academics advocate for supply chain networks to adopt an ecosystemic structure in order to increase their resilience and sustainability, there is a dearth of literature describing the precise procedures that enable the conversion of supply chains into ecosystems. The existing research indicates that a significant proportion, exceeding two-thirds of supply chain networks, encounter difficulties in transitioning into ecosystems. Notwithstanding the potential advantages that supply chain networks could reap from transitioning into ecosystems, a gap in understanding persists regarding the process of such a transformation. There is a limited amount of literature available regarding the optimal integration of information technology within supply chains as well as the appropriate levels at which such integration should occur within business processes and decision-making. This study adopts a grounded theory perspective to investigate the manner in which supply chain networks within the healthcare supply chain in Ghana expand their networks into ecosystems. The research focus has been directed towards the healthcare supply chain in Ghana due to the current efforts towards digitization and platformization. These efforts aim to enhance the ecosystemic orientation of supply chain networks within the sector. The primary aim of this investigation is to examine the mechanisms through which supply chain networks evolve into supply chain ecosystems through digital transformation and integrative capabilities. The author employs a qualitative approach and a case study design to utilize snowball sampling in order to ascertain the supply chain network of selected healthcare facilities in Ghana.  The present study employs social network analysis and thematic analysis techniques to analyze the transcribed interviews to explore the transformation processes across supply chain networks and how they integrate technology.