Automotive ergonomics deals with packaging human in the most convenient and effective way at an early stage in the vehicle architecture. Vehicle architecture comprises of numerous measurement variables which interact with each other and affect different functionalities like ergonomics, aerodynamics, safety, powertrain, etc. The purpose of this study is to identify unique drivers that influence performance of ergonomics in passenger cars and develop a structural model which will enable the car manufacturers to integrate these unique drivers in the early phase of vehicle conceptualization and development. An exhaustive list of drivers is identified based on the analysis of the existing literature and opinions from experts. Total Interpretive Structural Modelling (TISM) approach was utilized and constructed a structural model which shows the hierarchy of drivers of ergonomic performance. According to the proposed structural model, the drivers are classified into 2 levels based on their interaction and influence. The outcome of this research can assist researchers and automotive ergonomic practitioners to make decisions by appropriately prioritizing the drivers. This research is a novel approach, as it proposes a structural model considering the identified drivers using TISM approach in the field of automotive ergonomics for the first time and examines the interrelationships among the identified drivers for improving ergonomic performance in passenger cars.