The increased e-commerce volume, especially with the pandemic, has shown us that the supply chain should never be broken. Transportation, which is the most crucial element that connects the rings along the chain, has become more critical. In the face of this situation, almost the whole world has faced the problem of truck driver shortage that has never been mentioned before. The accident caused by the truck drivers, which we already have problems with in terms of numbers, causes enormous losses in the chain such as high cost, time, and stock out. Therefore, the primary purpose of this study is to identify the various barriers that are critical to the success of truck drivers in providing safe transportation and to determine the weights and relative importance of these barriers. To find answers to these questions, firstly, a detailed literature review is conducted to identify the barriers and challenges. Later, to find the effects of these barriers within themselves, the Best-worst method (BWM) is used, which is one of the decision-making models. With this method, the importance order of barriers is determined from a holistic perspective. Based on the results use of mobile phones is the most critical barrier among the sub-barriers. If it is necessary to sort among all barriers; the age of the driver, experience of the driver and eating & drinking in the car follow looking at external objects, respectively. Surprisingly, the aggressive driver behaviors barrier came in at the bottom of the overall barrier ranking. Based on these results, this study gives the reader a comprehensive insight into how detected barriers affect truck driver performance. Therefore, this framework is a roadmap that is designed with a holistic view to guide manufacturers, logistics parties, and even policy and decision-makers.