The ongoing COVID-19 pandemic has caused a global impact in every possible way. However, COVID-19 effects have been the most severe in the tourism and leisure industry due to public health measures and travel restrictions. Once the vaccines have been rolled out to public use, Thailand showed a strong attempt to introduce a so-called COVID-19 Vaccine Passport. It is untimely to present the identification framework given worries about the unquantifiable risk. Hence, the objective of this study is to identify the key factors affecting issuance of COVID-19 vaccine passport in Thailand and propose the optimal solutions for COVID-19 vaccine passport that will benefit stakeholders in Thailand’s tourism supply chain. Understanding the factors affecting this will lead to success in implementation. A review of diverse publications was used to identify the factors. The major factors identified as (F1) health safety, (F2) area of implementation, (F3) ethical, (F4) support system, (F5) expenditure and (F6) duration of use. The study employs Analytic Hierarchy Process (AHP) and a questionnaire of experts was used as a quantitative research approach. Factors are assumed to be independent. It is expected that the hierarchical structure would be able to provide a better view of the factors. This study results will provide a useful insight of Thailand’s tourism supply chain stakeholders toward the factors affecting the issuing of COVID-19 vaccine passport as well as suggestions. It is beneficial for Thailand’s tourism stakeholder by considering the critical factors impacting issuance of COVID-19 vaccine passport to design the future preparation effectively. This study also discusses possible directions for future research as well as provide additional perspectives in this area.