This study examines the impacts of remote work on the physical health, mental well-being, and social relationships of administrative staff at a public educational institution in southern Brazil. Combining ergonomic principles and multivariate analysis, the research employs the k-modes clustering technique to identify patterns in remote work experiences based on structured questionnaire data. The analysis revealed four distinct experience profiles with significant differences in infrastructure, organizational communication, cognitive load, and interpersonal relationships. Although remote work presented benefits such as schedule flexibility and improved quality of life, challenges emerged, including increased stress, reduced concentration, and ergonomic inadequacies. The findings highlight the need for institutional policies that ensure technical support, adequate infrastructure, and strategies for time management and mental health. This study contributes to the development of sustainable hybrid work models through an interdisciplinary and data-driven approach..