The objective of this research is to analyze the disruptive technologies that support business sustainability within the framework of digital transformation and industry 4.0.  In this context, qualitative research is carried out through a systematic literature review of industrial revolutions, disruptive technologies, and business sustainability. The results show that some disruptive technologies such as: Blockchain, Big Data, Internet of Things and Artificial Intelligence are relevant in supporting some business sustainability programs. This suggests a strong practical impact on the way we use some technologies for our daily activities, as well as, the way we work, live, and buy/consume products and services.  It is expected that some disruptive technologies gain more access to society and economy soon, and become affordable, and therefore have a stronger impact allowing companies and industries to support their business sustainability program and goals.