This study aimed to establish the impact of supervision and the work climate on the job satisfaction of nurses by supporting roles in the hospital room of the Mother and Child Hospital of the Motherland. This style of study is retrospective with a survey procedure and a cross-section approach. The study instrument used a questionnaire to 100 nurses in the inpatient room of RSKD Ibu and Anak Pertiwi on supervision, work climate, career promotion, and job satisfaction. Study data has been analyzed using route analysis. The findings of the research showed that the significant impact of supervision (X1) was 0.097>0.05, indicating that Ha was not effectively adopted, there was no significant influence (constant value 0.870) of management (X1) on promotion (Y). The work environment (X2) of 0.098> 0.05 implies that Ha is not effectively approved. There is no significant impact (constant value of 1,000) of the work environment (X2) on promotion (Y). The considerable weight of Supervision (X1) of 0.000 <0.05 implies that Ha is successfully recognized, there is a significant impact (constant value of 0.415) of Supervision (X1) on work satisfaction (Z). The work environment (X2) of 0.024 <0.05 implies that Ha has been effectively recognized. There is a significant impact (constant value of 0.089) on the work environment (X2) on job satisfaction (Z). The considerable effect of the progression (Y) of 0.000 <0.05 implies that Ha has been effectively approved. There is a significant influence (constant value of 0.855) of the advertisement (Y) on work satisfaction (Z). The impact of supervision (X1) on the work satisfaction (Z) of nurses by advancement (Y) is 0.053> 0.05, which indicates that the indirect effect of job promotion is not entirely significant. The impact of the work environment (X2) on the job satisfaction (Z) of nurses by the upgrade (Y) is 0.054> 0.05, which indicates that the indirect influence by job promotion is not entirely essential.