As the market scale of fresh food e-commerce continues to expand and people's demand for various fresh foods increases, the last-mile distribution is the key point for the development of fresh food e-commerce. This paper would like to analyze 5 factors that affect the last-mile distribution of fresh e-commerce and to provide suggestions for the last-mile distribution of fresh food e-commerce enterprises and to propose optimization suggestions to help fresh food e-commerce enterprises adjust their future logistics development strategies in time, also to promote the stable development, including consumer experience, warehouse operation, costs, waste, transportation and distribution. The results showed that the main criteria affecting the last-mile distribution of fresh food e-commerce is costs, and its average weight is 0.420, which indicates that the costs is the most important to promote the development of fresh food e-commerce. The weight of transportation costs in sub-criteria is 0.240, which indicates that the transportation costs of fresh food is important.